It is well accepted that angiotensin-converting enzyme (ACE) inhibitors are contraindicated during the second and third trimesters of pregnancy because of increased risk of fetal renal damage. First-trimester use, however, has not been linked to adverse fetal outcomes.
Are ACE inhibitors bad for pregnancy?
The use of an ACE inhibitor during the second and third trimesters of pregnancy has been associated with a number of serious foetal malformations including oligohydramnios, foetal and neonatal renal failure, bony malformations, limb contractures, pulmonary hypoplasia, prolonged hypotension and neonatal death.
Why are ACEI and ARBs contraindicated in pregnancy?
Background: Drugs that affect the renin-angiotensin system, such as angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors are not typically recommended for pregnant women because of their potential fetal toxicity.
What is the safest blood pressure medication during pregnancy?
Methyldopa has been used for decades to treat high blood pressure in pregnancy and it appears to be safe. Labetalol has been extensively studied and has become increasing prescribed in pregnancy. Labetalol is now commonly used as a first-line treatment choice.
When should I stop taking ACE inhibitors before pregnancy?
Antihypertensive treatment should be discontinued in women taking ACE inhibitors or ARBs if they become pregnant (preferably within two working days of notification of pregnancy) as ACE inhibitors and ARBs are teratogenic, with increased risk of congenital abnormalities if taken during early pregnancy, and they are …
Why do ACE inhibitors cause birth defects?
When lisinopril, or any ACE inhibitor, is taken during the second or third trimesters of pregnancy, it can cause low levels of amniotic fluid (the fluid that surrounds the baby). Low levels of amniotic fluid can lead to health problems for the developing baby.
What pregnancy category are ACE inhibitors?
Currently, ACE inhibitors are pregnancy category C in the first trimester and category D in the second and third trimesters. Most malformations identified were various cardiac septal defects.
Are ACE inhibitors teratogenic?
Specifically, these drugs were associated with increased infant risks for cardiovascular and nervous system anomalies. ACE inhibitors, long known to be teratogenic when used in the last two trimesters of pregnancy, have been considered safe in the first trimester.
Why is hydralazine given during pregnancy?
For many years, hydralazine has been the recommended antihypertensive of first choice for severe hypertension in pregnancy. Its side effects (such as headache, nausea, and vomiting) are common and mimic symptoms of deteriorating pre-eclampsia.
Are thiazide diuretics safe in pregnancy?
Use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice or thrombocytopenia. Since they do not prevent or alter the course of EPH (Edema, Proteinuria, Hypertension) gestosis (pre-eclampsia), these drugs must not be used to treat hypertension in pregnant women.
Can you take blood pressure meds while pregnant?
Some blood pressure medications are considered safe to use during pregnancy, but angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers and renin inhibitors are generally avoided during pregnancy.
What is the drug of choice for preeclampsia?
Background: Eclampsia, the occurrence of a seizure in association with preeclampsia, is rare but potentially life-threatening. Magnesium sulfate is the drug of choice for treating eclampsia.
Can I take atenolol while pregnant?
Atenolol and Pregnancy
Atenolol can cause fetal harm when administered to a pregnant woman. Atenolol crosses the placental barrier and appears in cord blood. Atenolol use in pregnant women resulted in children born small in size with low sugar and slow heart rate.
Is lisinopril HCTZ safe during pregnancy?
IMPORTANT WARNING: has been expanded. Do not take lisinopril and hydrochlorothiazide if you are pregnant. If you become pregnant while taking lisinopril and hydrochlorothiazide, call your doctor immediately. Lisinopril and hydrochlorothiazide may harm the fetus.
Why are diuretics contraindicated in pregnancy?
Diuretics do not cause fetal malformations but are generally avoided in pregnancy, as they prevent the physiologic volume expansion seen in normal pregnancy. They may be used in states of volume-dependent hypertension, such as renal or cardiac disease.